On-demand aircraft conceptual design and development

Issued as final reportNational Institute of Aerospac

La responsabilidad civil derivada de la vulneración del derecho a la intimidad y al honor mediante redes sociales en el Perú al año 2017

La presente investigación titulada “La responsabilidad civil derivada de la vulneración del derecho a la intimidad y al honor mediante redes sociales en el Perú al año 2017”, tiene como objetivo general Determinar de qué forma se establece la responsabilidad civil derivada de la vulneración del derecho a la intimidad y al honor mediante redes sociales en el Perú al año 2017. La investigación tiene diseño no experimental y descriptivo; para recoger los datos se aplicó una encuesta a 30 usuarios de redes sociales, a fin de identificar si se han visto afectados en el derecho a la intimidad y al honor mediante la difusión de información a través de las redes sociales, la misma que está representada mediante cuadros y gráficos con una interpretación clara

Activation and Cleavage of the N-O Bond in Dinuclear Mixed-Metal Nitrosyl Systems and Comparative Analysis of Carbon Monoxide, Dinitrogen, and Nitric Oxide Activation

The activation and scission of the N–O bond in nitric oxide using dinuclear mixed-metal species, comprising transition elements with d3 and d2 configurations and trisamide ligand systems, have been investigated by means of density functional calculations. The [Cr(III)–V(III)] system is analyzed in detail and, for comparative purposes, the [Mo(III)–Nb(III)], [W(III)–Ta(III)], and (mixed-row) [Mo(III)–V(III)] systems are also considered. The overall reaction and individual intermediate steps are favourable for all systems, including the case where first row (Cr and V) metals are exclusively involved, a result that has not been observed for the related dinitrogen and carbon monoxide systems. In contrast to the cleavage of dinitrogen by three-coordinate Mo amide complexes where the dinuclear intermediate possesses a linear [Mo–NN–Mo] core, the [M–NO–M′] core must undergo significant bending in order to stabilize the dinuclear species sufficiently for the reaction to proceed beyond the formation of the nitrosyl encounter complex. A comparative bonding analysis of nitric oxide, dinitrogen and carbon monoxide activation is also presented. The overall results indicate that the π interactions are the dominant factor in the bonding across the [M–L1L2–M′] (L1L2 = N–O, N–N, C–O) moiety and, consequently, the activation of the L1–L2 bond. These trends arise from the fact that the energy gaps between the π orbitals on the metal and small molecule fragments are much more favourable than for the corresponding σ orbitals. The π energy gaps decrease in the order [NO \u3c N2 \u3c CO] and consequently, for each individual π orbital interaction, the back donation between the metal and small molecule increases in the order [CO \u3c N2 \u3c NO]. These results are in accord with previous findings suggesting that optimization of the π interactions plays a central role in increasing the ability of these transition metal systems to activate and cleave small molecule bonds

Instrucción escolar y pobreza monetaria, en el centro poblado Poncoy del distrito de Monsefú, 2022

Los logros académicos son vitales para una correcta inserción laboral en el Perú, para ello en la presente investigación se detalla la alarmante situación escolar entre los pobladores de Poncoy, teniendo como objetivos determinar si efectivamente el déficit de instrucción escolar se vincula a la pobreza monetaria en el centro poblado de Poncoy del distrito de Monsefú, 2022 y determinar la correlación entre el déficit de la instrucción escolar y la pobreza monetaria en dicha población. En este sentido, se evidenció que el déficit de la instrucción escolar estuvo vinculado a la pobreza monetaria, la metodología usada en el estudio fue de enfoque cualitativo, co-relacional de diseño no experimental, de secuencia transversal por su propósito aplicada y su acercamiento a los hechos en campo, se consideró a 50 pobladores como sujetos de la investigación que en su mayoría fueron mujeres y se trabajó la técnica de la entrevista con la aplicación del instrumento guía de entrevista mixta la cual contenía 11 preguntas entre abiertas y cerradas. Se concluyó con la correlación del déficit de la instrucción escolar y la pobreza monetaria entre la población de Poncoy debido a sus limitados logros escolares es que su condición económica se halló desfavorecida para conseguir un trabajo digno.TesisComunicación y desarrollo human

Estilos de desarrollo sustentable en el norte de Misiones

This article provides an approach to the field of conservation and sustainable development in the north of Misiones. The centerpiece is the ways in which environmental agencies face projections and interventions conservation in buffer zones of Protected Natural Areas. The first characterizes the departments of General Manuel Belgrano Iguaçu and the beginnings of the formation of environmental governance. It then describes the main projects for the conservation and sustainable development stimulated by JICA (Japan International Cooperation Agency) and AECI (Spanish Agency for International Development). Specifically, the key features of "Project Cabureí" (JICA) and the designs produced by Araucaria XXI (AECI). For the signal., Problem sets considerations applicants who meet the local communities and environmental agencies.Este trabajo realiza un acercamiento a la esfera de la conservación y el desarrollo sustentable en el norte de Misiones. El eje central son los modos en que agencias ambientalistas encaran proyecciones e intervenciones conservacionistas em zonas de amortiguamiento de Áreas Naturales Protegidas. Al principio se esboza una caracterización de los departamentos de Iguazú y General Manuel Belgrano, así como de los inicios de la conformación de una gobernanza medioambiental. Luego se describen los principales proyectos de conservación y desarrollo sustentable estimulados por JICA (Japan International Cooperation Agency), y por AECID (Agencia Española de Cooperación Internacional para el Desarrollo). De manera concreta, las características principales del “Proyecto Cabureí” (JICA) así como de los proyectos producidos por Araucaria XXI (AECID). Hacia el .nal, se exponen consideraciones sobre problemáticas recorrentes que reúnen a poblaciones locales y agencias ambientalistas.Este trabajo realiza un acercamiento a la esfera de la conservación y el desarrollo sustentable en el norte de Misiones. El eje central son los modos en que agencias ambientalistas encaran proyecciones e intervenciones conservacionistas em zonas de amortiguamiento de Áreas Naturales Protegidas. Al principio se esboza una caracterización de los departamentos de Iguazú y General Manuel Belgrano, así como de los inicios de la conformación de una gobernanza medioambiental. Luego se describen los principales proyectos de conservación y desarrollo sustentable estimulados por JICA (Japan International Cooperation Agency), y por AECID (Agencia Española de Cooperación Internacional para el Desarrollo). De manera concreta, las características principales del “Proyecto Cabureí” (JICA) así como de los proyectos producidos por Araucaria XXI (AECID). Hacia el .nal, se exponen consideraciones sobre problemáticas recorrentes que reúnen a poblaciones locales y agencias ambientalistas

Weight loss dynamics during combined fluoxetine and olanzapine treatment

BACKGROUND: Fluoxetine and olanzapine combination therapy is rapidly becoming an effective strategy for managing symptoms of treatment-resistant depression. Determining drug-drug interactions, drug metabolism and pharmacokinetics is of particular interest for revealing potential liabilities associated with drug augmentation in special patient populations. In the current studies, we chronically administered fluoxetine and olanzapine in non-stressed rats to extend our previous findings regarding body weight dynamics. RESULTS: Chronic fluoxetine (10 mg/kg) and olanzapine (5 mg/kg and 0.5 mg/kg) treatment decreased weight gain irrespective of olanzapine dosing. At the 10 mg/kg and 5 mg/kg dose, respectively, fluoxetine and olanzapine also significantly reduced food and water consumption. This pharmacodynamic event-related effect, however, was not observed at the 10 mg/kg and 0.5 mg/kg dosing paradigm suggesting differences in tolerability rates as a function of olanzapine dose. The decrease in weight gain was not associated with apparent changes in glucose metabolism as vehicle- and drug-treated rats showed undistinguishable serum glucose levels. The combination of fluoxetine and olanzapine in rats yielded drug plasma concentrations that fell within an expected therapeutic range for these drugs in psychiatric patients. CONCLUSIONS: These data suggest that fluoxetine and olanzapine treatment decreases weight gain in rats; a pharmacodynamic event-related effect that differs considerably from what is observed in the clinical condition. The possibility of mismatched models regarding body weight changes during drug augmentation therapy should be seriously considered

Prognostic significance of new onset ascites in patients with pancreatic cancer

BACKGROUND: The purpose of this study was to determine risk factors for development of malignant ascites and its prognostic significance in patients with pancreatic cancer. METHODS: A prospective database was queried to identify patients with pancreatic cancer who develop ascites. Stage at presentation, size, and location of primary tumor, treatment received and length of survival after onset of ascites were determined. RESULTS: A total of 15 patients were identified. Of which 4 patients (1 stage II, 3 stage III) underwent pancreaticoduodenectomy and manifested with ascites 2, 3, 24 and 47 months after surgery (tumor size 2.9 ± 1.32 cm). All but one of the remaining 11 patients (tumor size 4.4 ± 3.38 cm) presented with metastatic disease, and all developed malignant ascites 9 months after diagnosis, dying 2 months later. Resected patients lived longer before the onset of ascites, but not after. CONCLUSION: Once diagnosed, ascites in pancreatic cancer patients heralds imminent death. Limited survival should be considered when determining the aggressiveness of further intervention

The afterglow of GW170817 from every angle: Prospects for detecting the afterglows of binary neutron star mergers

To date GW170817, produced by a binary neutron star (BNS) merger, is the only gravitational wave event with an electromagnetic (EM) counterpart. It was associated with a prompt short gamma-ray burst (GRB), an optical kilonova, and the afterglow of a structured, off-axis relativistic jet. We model the prospects for future mergers discovered in gravitational waves to produce detectable afterglows. Using a model fit to GW170817, we assume all BNS mergers produce jets with the same parameters, and model the afterglow luminosity for a full distribution of observer angles, ISM densities, and distances. We find that in the LIGO/Virgo O4 run, 30% - 50% of BNS mergers with a well-localized counterpart will have an afterglow detectable with current instrumentation in the X-ray, radio and optical. Without a previously detected counterpart, up to 18% will have an afterglow detectable by wide-area radio and optical surveys, compared to only about 5% of events expected to have bright (on-axis) gamma-ray emission. Therefore, most afterglows that are detected will be from off-axis jets. Further in the future, in the A+ era (O5), 50% - 60% of mergers will have afterglows detectable with next-generation X-ray and radio instruments. Future wide-area radio survey instruments, particularly DSA-2000, could detect 50% of afterglows, even without a kilonova counterpart. Finding and monitoring these afterglows will provide valuable insight into the structure and diversity of relativistic jets, the rate at which mergers produce jets, and constrain the angle of the mergers relative to our line of sight.Comment: Submitted to MNRA